In addition to strong correlation of cytolytic activity with transcriptional and genetic subtypes of the cancer, further analysis showed that EC with low CYT tended to be harbored accelerated genomic structural variations, particularly MYC, CCNE1, and FGFR3 amplifications and/or deletions of PTEN and TP73 tumor suppressor genes. This evidence concerns the gene FGFR3 and cancer.