SETBP1 and neoplasm: In addition, SETBP1 expression was significantly different in groups classified according to tumor differentiation (P<0.0001), where SETBP1 expression was significantly higher in the poor group (G3, poorly differentiated; G4, undifferentiated) compared to the well or moderate groups (G1, well-differentiated; G2, moderately differentiated; Figure 1B).