YBX1 and HELLP syndrome: For instance, LINC-HELLP, a 205 kb-lncRNA, is found to be involved in regulating splicing and the pathogenesis of HELLP syndrome related to pregnancy.The mass spectrometry and purification experiments found that components of splicing such as the splicing-related factors Y-Box Binding Protein 1 (YBX1), Poly(RC) Binding Proteins 1 and 2 in addition to the the ribosomal machinery,can detect this lncRNA.