To explore whether CD147 expression is associated with 5-FU resistance in CRC patients, we analyzed CD147 mRNA and protein expression in primary tumor samples of three groups of TNM stage III or IV CRC patients: a no chemotherapy group (without preoperative chemotherapy), a response group (good response to preoperative fluorouracil analog–based chemotherapy), and a no response group (poor response to preoperative fluorouracil analog–based chemotherapy) (Supplementary Table 5). This evidence concerns the gene BSG and neoplasm.