It has also been reported that the overexpression rate of EGFR in esophageal squamous cell carcinoma (ESCC) is nearly 60%–70%, gene amplification 28% (15), and there is a close correlation between overexpression of EGFR and poor prognosis (16), which all indicates that EGFR may be one of the effective targets in the treatment of CEC. The gene discussed is EGFR; the disease is esophageal squamous cell carcinoma.