However, M2-like TAMs consist of low efficiency of antigen presentation and promote cancer progression through the production of the immunosuppressive cytokines, such as IL-10 and transforming growth factor-β (TGF-β), which have been identified as the main factor of immunosuppression and the marker of poor prognosis in the tumor microenvironment (64). This evidence concerns the gene TGFB1 and neoplasm.