AIFM2 and glioblastoma: On the other hand, one possible explanation for the strong resistance of GBM cells to the induction of ferroptosis is the protective effect exhibited by FSP1 in this type of tumor (Figure 4), since most GBM cells express high levels of this protein, and cotreatment with iFSP1 and RSL-3 strongly sensitizes them to ferroptosis (54, 72).