Thus, although many tumor cells can evade apoptosis and necroptosis due to their low expression of key genes for the activation of these pathways (Figure 1B) (1, 10, 11), RNA-seq data show that most cancer cells have high expression levels of SLC7A11 and GPX4 (https://portals.broadinstitute.org/ccle). The gene discussed is GPX4; the disease is cancer.