In another study, metformin sensitizes progestin in endometrial cancer through downregulation of Ten-eleven translocation 1 (TET1), a dioxygenase responsible for transferring 5-methylcytosine into 5-hydroxymethylation and CpG islands enriched in the promoter region of Glo1 are possible target of TET1. Here, GLO1 is linked to endometrial cancer.