PLK2 and neuroblastoma: Oxidative stress might play a key role in PLK2 phosphorylation of α-Syn, and antioxidant NAC could completely block iron-induced up-regulation of PLK2, CK2 and p-Ser129 α-Syn (140); However, as PLK2 induces elevation of α-Syn in copper-treated SHSY5Y neuroblastoma cells, both PP2A level and oxidative status remains unchanged (153).