Circ_0102049 could heighten PLK2 expression by depressing miR-520g-3p, and inhibit proliferation, invasion, migration and cell cycle of osteosarcoma (OS) cell line MG63; PLK2 inhibiting leads to a significant elevation in tumor volume and weight in the MG63 cell xenograft mouse model (14). The gene discussed is PLK2; the disease is osteosarcoma.