And, in SGC-7901, PLK2 might be inhibited by anti-tumor miR-126; But PLK2 was still identified tumor suppressive in SGC-7901, because the tumor inhibition of miR-126 might be a symphonic regulation of PLK2, PI3KR2 and Crk; The limitation of this study was the lack of direct intervention on these effectors in SGC-7901 cell line to clarify their exact role (124). The gene discussed is CRK; the disease is neoplasm.