PLK2 and osteosarcoma: Histone deacetylase inhibitor trichostatin A (TSA) could induce upregulated PLK2 expression in human osteosarcoma cell line (MG-63), which may be resulted from TSA-induced GATA-1 acetylation enhancing its DNA-binding ability and initiating the PLK2 promoter, indicating acetylation promoting PLK2 expression (19).