However, our group has recently published a separate companion study with similar ET-1-induced stroke lesion (Ermine et al.).31 In this study we described results from the histological assessment at different time points (1, 4, 12, 24, 36 and 48 weeks) and showed a minimal neuronal loss in shams at the injection site at 1 week but resolved by 4 weeks. This evidence concerns the gene EDN1 and Stroke.