Likewise, a similar effect was observed for a blueberry leaf extract in pancreatic MIN6 B cells with improvement in insulin signaling while in vivo extract was able to decrease body weight, plasma glucose, hemoglobin A1c (HbA1c), homeostatic model assessment for insulin resistance (HOMA-IR), triglycerides, and nonesterified fatty acids (NEFAs) levels in mice fed with high-fat diet [35]. Here, INS is linked to Insulin resistance.