For the engineered S. cerevisiae expressing gcH2A-11, twelve pathways including Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway, Toll-like receptor signaling pathway, Salmonella infection, C-type lectin receptor signaling pathway, Necroptosis, Apoptosis, MAPK signaling pathway, RIG-I-like receptor signaling pathway, Complement and coagulation cascades and Cytosolic DNA-sensing pathway were significantly enriched for the up-regulated DEGs based on that corrected q value < 0.05 (Figure 4C). Here, CLEC4D is linked to Salmonella Infections.