More importantly, high expression levels of HAVCR2 on immune cells including CD8+ T cells, CD4+ T cells, and macrophages plus high expression levels of LGALS9 on endothelial cells and endocrine cells (Figure 11I) indicated that endothelial cells and endocrine cells may suppress immune cells activation and induce immunosuppressive tumor microenvironment. The gene discussed is HAVCR2; the disease is neoplasm.