Additional works unraveled alterations across all the immune system, possibly linked to the pleiotropic clinical features in DADA2 (Figure 1): an intrinsic defect of B cell compartment may be related not only to recurrent and chronic infections (12, 18, 27), but also to autoimmunity development (18, 48, 75), which can be additionally influenced by a T reg defect (12) and an hyperactivation of IFN type axis (12, 37, 44–48, 78). The gene discussed is IFNA1; the disease is Autoimmunity.