The regulation of BDNF-AS on seizure activities probably attribute to its activation of mTOR by inhibiting ribonuclease inhibitor 1 (RNH1)-mediated mTOR mRNA decay, as well as the controlling on the production of BDNF related inflammatory cytokines, such as TNF-α, IL-2, IL-6 (196, 197) and MALAT1, participates in the anti-inflammatory processes and regulates autophagy in endothelial cells and neurons by interacting with mTOR pathway in epilepsy (198–201). The gene discussed is TNF; the disease is epilepsy.