Furthermore, mutation of dynein cytoplasmic 2 heavy chain 1 (DYNC2H1), HECT and RLD domain-containing E3 ubiquitin protein ligase family member 1 (HERC1), and solute carrier family 26 member 7 (SLC26A7) was easier to be detected in HCC patients from the low-CRRS group (p < 0.01, Figure 5C), and BAP1, sperm antigen with calponin homology and coiled-coil domains 1 (SPECC1), TP53, and thyroglobulin (TG) had a significantly higher mutant frequency in HCC patients from the high-CRRS group (p < 0.01, Figure 5C). This evidence concerns the gene SPECC1 and hepatocellular carcinoma.