PFKFB3 and cancer: Forkhead box M1 (FOXM1), a known transcription factor promoting glycolysis in some cancers by binding to the promoters of glycolytic enzyme genes including lactate dehydrogenase A (LDHA), hexokinase 1 (HK1), glucose transporters (GLUTs), and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), was also increased in expression in patients in the high-CRRS group (Figure 4C) (37).