This knowledge is of great importance for the future strategy of combined therapy, inducing cuproptosis or ferroptosis and targeting multiple pathways such as the rat sarcoma viral oncogene (RAS)/ Raf-1 proto-oncogene (RAF)/ mitogen-activated protein kinase kinase (MEK)/ extracellular signal-regulated protein kinase (ERK) pathway, in HCC and may lead to improved prognosis of these patients (64). The gene discussed is MAP2K7; the disease is hepatocellular carcinoma.