PKM and hepatocellular carcinoma: Many genes encoding enzymes of the glycolytic pathway, such as hexokinase 2 (HK2), pyruvate kinase M1/2 (PKM), lactate dehydrogenase B (LDHB), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), were all significantly upregulated in HCC patients with high CRRS (Figure 4C) (36).