Animal studies have demonstrated that IL-10-/- mice with IL-6 deficiency showed more severe colitis and more aggressive disease progression, and developed systemic inflammation that was absent in IL-10-/- mice without IL-6 deficiency (57), indicating that IL-6 may promote IL-10 independent mechanism of Treg cells suppression function. The gene discussed is IL10; the disease is hyperinsulinemic hypoglycemia, familial, 4.