CYFIP2 and nonpapillary renal cell carcinoma: An investigation focused on the downregulation of CYFIP2 in clear cell renal cell carcinoma (ccRCC) revealed that several immune markers were critically correlated with CYFIP2 expression, especially with CD4+ cells and CD8+ cells, which could act as a tumor suppressor gene in ccRCC and create a novel strategy in clinical treatment (31).