Cocaine addiction, glycerolipid hematopoietic cell lineage,i immune network for production, and primary immunodeficiency were significantly enriched in the high CYFIP2 subgroup, whereas allograft rejection, the intestinal immune network for IgA production, nicotinate and nicotinamide metabolism, and primary immunodeficiency were significantly enriched in the low CYFIP2 subgroup (Supplementary Figure 3B). The gene discussed is CYFIP2; the disease is inborn error of immunity.