The histogram exhibits that JMJD8 was significantly associated with immune subtypes in 10 cancers (Figure 7C), the top 6 of which are presented in Figure 7D; JMJD8 expression increased in the C4 subtype in BLCA, UCEC, and LUAD, implying its reverse association with lymphocyte functions. This evidence concerns the gene C4A and bladder transitional cell carcinoma.