For experimental validation, we performed multiple fluorescence (H&E staining images are presented in Supplementary Material S4) staining in pan-cancer paraffin sections, and the photos of JMJD8, CD68, and CD163 staining showed their co-expression in 7 cancers (BLCA, PUC/PRUC, ureter urothelial cell carcinoma (UCC), UCEC, LGG, TGCT, and PRAD) (Figures 9A–I). The gene discussed is CD68; the disease is cancer.