NFKB1 and cancer: PTL, with known potent anti-cancer and anti-inflammatory properties, is a SL originally isolated from the plant Tanacetum parthenium, PTL plays anti-inflammatory effect through an underlying mechanism, and the mechanism attenuates the production of inflammatory mediators possibly via inhibiting the Toll-like receptor 4-mediated activation of Akt, mTOR, and NF-κB pathways to attenuate the production of inflammatory mediators [4].