Furthermore, the hub bio-targets of calycosin against HF and DM were screened, namely, MAPK1, ARRB1, ABL1, CDK1, MAP3K3, STUB1, PPP1CA, STAT3, PML, IQGAP1, HSPA9, CAV1, KPNB1, SQSTM1, RUVBL1, SFPQ, PPP2CA, PCBP1, ANXA2, and PAK1. Here, ABL1 is linked to diabetes mellitus.