PAK1 and diabetes mellitus: Furthermore, the hub bio-targets of calycosin against HF and DM were screened, namely, MAPK1, ARRB1, ABL1, CDK1, MAP3K3, STUB1, PPP1CA, STAT3, PML, IQGAP1, HSPA9, CAV1, KPNB1, SQSTM1, RUVBL1, SFPQ, PPP2CA, PCBP1, ANXA2, and PAK1.