In further determination using the molecular docking analysis, the core targets of MAPK1 (1TVO), ARRB1 (1ZSH), and ABL1 (1FPU) in HF and DM showed the best binding activities with calycosin, indicating that these three genes may be potent pharmacological targets of calycosin against HF and DM. Here, MAPK1 is linked to hydrops fetalis.