Furthermore, the hub bio-targets of calycosin against HF and DM were screened, namely, MAPK1, ARRB1, ABL1, CDK1, MAP3K3, STUB1, PPP1CA, STAT3, PML, IQGAP1, HSPA9, CAV1, KPNB1, SQSTM1, RUVBL1, SFPQ, PPP2CA, PCBP1, ANXA2, and PAK1. Here, ANXA2 is linked to hydrops fetalis.