Furthermore, the hub bio-targets of calycosin against HF and DM were screened, namely, MAPK1, ARRB1, ABL1, CDK1, MAP3K3, STUB1, PPP1CA, STAT3, PML, IQGAP1, HSPA9, CAV1, KPNB1, SQSTM1, RUVBL1, SFPQ, PPP2CA, PCBP1, ANXA2, and PAK1. Here, HSPA9 is linked to diabetes mellitus.