The primary signaling pathways comprised proteoglycans in cancer, oocyte meiosis, acute myeloid leukemia, the chemokine signaling pathway, focal adhesion, regulation of actin cytoskeleton, Epidermal Growth Factor Receptor (ErbB) signaling pathway, MAPK signaling pathway, neurotrophin signaling pathway, axon guidance, hepatitis C, adrenergic signaling in cardiomyocytes, pathways in cancer, herpes simplex infection, Cyclic Adenosine Monophosphate (cAMP) signaling pathway, and viral carcinogenesis (Figures 4A–C). This evidence concerns the gene BDNF and acute myeloid leukemia.