BCL2 and acute myeloid leukemia: In normal cells, the apoptotic pathway is regulated by extrinsic and intrinsicpathways with tight control of the intrinsic pathway regulated by the B-celllymphoma-2 (BCL2) protein family.68,69 FDA-approved venetoclax, ahighly selective BCL2 inhibitor, changed the treatment paradigm forming a newstandard-of-care for newly diagnosed older adults with AML who are ineligible forintensive chemotherapy.