AQP4 and Cognitive impairment: Many neurological conditions are now found to be associated with an alteration in AQP4 expression or localization, such as CNS inflammation, glymphatic fluid clearance, synaptic plasticity and memory formation, cognitive deficits, regulation of extracellular space (ECS) volume and potassium homeostasis, chronic pain, and neuropathic pain (Nesic et al., 2005; Nagelhus and Ottersen, 2013; Jiang et al., 2017; Hubbard et al., 2018; Lu G. et al., 2020; Lu H. et al., 2020).