The study of Wang et al. has confirmed that BHB can antagonize the decrease of SNTA1 expression by inhibiting histone deacetylase 1 (HDAC1) expression and thus restore AQP4 polarity in mice with Alzheimer’s disease, and it was concordant with the results of Wang et al. (2019) and Li et al. (2020). Here, HDAC1 is linked to early-onset autosomal dominant Alzheimer disease.