AQP4 and early-onset autosomal dominant Alzheimer disease: Changes in AQP4 expression and localization have been manifested in several CNS disorders, including traumatic brain injury, Alzheimer’s disease, chronic pain, and cognitive deficiency associated with diabetes (Kress et al., 2014; Peng et al., 2016; Jiang et al., 2017; Lu G. et al., 2020).