AJUBA and esophageal squamous cell carcinoma: Although a number of studies have indicated that AJUBA plays an oncogene role to promote tumorigenesis, several literatures also demonstrated that AJUBA inhibits cell growth via targeting of β-catenin and YAP signaling in hepatocellular carcinoma (Liu et al., 2018), and AJUBA might play a tumor suppressor role in ESCC (Zhang et al., 2015).