NRG1 and heart disorder: Activating either NRG1 (Bersell et al., 2009; Cohen et al., 2014; Polizzotti et al., 2015) or ErbB2/4 (Bersell et al., 2009; Belmonte et al., 2015; D'Uva et al., 2015) improved CM proliferation, suggesting that the NRG1/Erb signaling pathway is conserved and thus might serve as an effective therapeutic strategy for heart diseases.