In melanoma, ADAR1 controls the expression of integrin beta 3 (ITGB3), a cell surface protein associated with tumor invasion (Pinon and Wehrle-Haller, 2011; Orgaz and Sanz-Moreno, 2013), via miR-22 and PAX6 transcription factor at the post-transcriptional and transcriptional levels. The gene discussed is ADAR; the disease is neoplasm.