ADAR and pancreatic ductal adenocarcinoma: CircNEIL3 and ADAR1 are upregulated in pancreatic ductal adenocarcinoma (PDAC) cells and tissues, and circNEIL3 as a miRNA sponge leads to down-regulation of miR-432-5p, thereby suppressing the down-regulation effect caused by the 3′UTR interaction of this microRNA with ADAR1 (Xu et al., 2020; Shen et al., 2021).