Certain pancreatic developmental genes such as nuclear receptor subfamily 5 group A member 2 (NR5A2), pancreatic and duodenal homeobox 1 (PDX1), and hepatocyte nuclear factor-1 alpha (HNF1A) have been identified as susceptibility factors for PC in T2DM patients. The gene discussed is HNF1A; the disease is pachyonychia congenita.