We used the following keywords and MeSH terms: (sodium glucose co-transporter 2 inhibitor) OR (sglt2 inhibitor)) AND (sympathetic nervous system)) OR (autonomic nervous system)) OR (sympathetic overactivity)) AND (cardiac protection)) OR (heart rate)) AND (drug effects)) AND (blood pressure)) OR (vascular stiffness)) AND (type 2 diabetes mellitus). The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.