It appears that the relationship between IL-6, AD and neurodegeneration depend on other pro-inflammatory and anti-inflammatory cytokines and different endophenotypic expression of inflammatory markers (Wang et al., 2015; Peng et al., 2020), in addition to IL-6 receptor polymorphisms (Su et al., 2016; Haddick et al., 2017; Zhang et al., 2021). Here, IL6 is linked to Alzheimer disease.