The objective of this study was to identify associations between sleepiness in CU older adults with (1) CSF biomarkers of AD pathology (Aβ42, p-tau, p-tau/Aβ42); (2) CSF biomarkers of neuroinflammation (IL-6, IL-10, TNF-α); and (3) a CSF biomarker of axonal integrity and neurodegeneration (NfL). Here, NEFL is linked to Alzheimer disease.