When compared to blood samples, CSF IL-6 levels have been found to be significantly higher in patients with multiple sclerosis (Stelmasiak et al., 2000), subarachnoid hemorrhage (Hopkins et al., 2012), ventriculostomy-related infection (Hopkins et al., 2012), bacterial meningitis (Beran et al., 2009), traumatic brain injury (Kossmann et al., 1995), and stroke (Tarkowski et al., 1995). This evidence concerns the gene IL6 and stroke disorder.