We previously did not find an association between EDS and Tau-PET among cognitively unimpaired (CU) older adults (Carvalho et al., 2020), though we did not examine associations of EDS with CSF biomarkers of AD pathology (Aβ42, p-tau, p-tau/Aβ42), which may change earlier than neuroimaging biomarkers of in vivo pathology in pre-clinical stages of AD (Jack et al., 2013; Guo et al., 2021). The gene discussed is MAPT; the disease is Alzheimer disease.