Subsequently, with possible early detection, accurate subtyping, and intensive monitoring being essential for an optimal result of SCLC therapy, the issue of SCLC being diagnosed at a later stage and drastically reducing curing rates of this aggressive malignancy will be at ease (Cummings et al., 2008; Fang et al., 2021).There are several potential markers carcinoembryonic antigen (CEA), Neuron-specific enolase (NSE), Progastrin releasing peptide (ProGRP), Creatine kinase BB (CK-BB), Chromogranin A (CgA), Neural cell adhesion molecule (NCAM) and several cytokeratins (Harmsma et al., 2013). This evidence concerns the gene GRP and small cell lung carcinoma.