NEAT1 and amyotrophic lateral sclerosis: For instance, ALS-linked intronic expansion of the human C9orf72 gene and potentially causative two long noncoding RNAs, NEAT1 (nuclear enriched abundant transcript 1) and MALAT1 (metastasis associated in lung adenocarcinoma transcript 1/NEAT2) contain abundant G4 motifs (Grigg et al., 2014; Haeusler et al., 2014; Simko et al., 2020; Mou et al., 2022).