The best characterized ALS-linked G4-RNA binding proteins, TDP-43 and FUS, share structural and functional similarities, including participation in ALS pathogenesis (Lagier-Tourenne and Cleveland, 2009; da Cruz and Cleveland, 2011; Strong and Volkening, 2011; Guerrero et al., 2016; Ratti and Buratti, 2016; Ishiguro et al., 2021). The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.