MMP9 and astrocytoma (excluding glioblastoma): Tanshinone IIA (12) inhibited astrocytoma migration by the down-regulation of cellular-myelocytomatosis viral oncogene (c-Myc), Bcl-2, and matrix metalloproteinase-9 (MMP-9) expression, and the up-regulation of transmembrane receptor notch homolog 1 (Notch-1) pathway [44].