In human colorectal cancer cells, tanshinone IIA (12) restrained β-catenin/VEGF-mediated angiogenesis by targeting transforming growth factor-β (TGF-β1) in normoxic and hypoxia-inducible factor 1α (HIF-1α) in hypoxic micro-environments [41]. The gene discussed is HIF1A; the disease is colorectal cancer.