NR4A1 and obesity due to melanocortin 4 receptor deficiency: Our recent study proposed the possibility of dual targeting of AMPKα and Nur77 as a potential antiadipogenic mechanism and confirmed that ISO, a sesquiterpene lactone found in Inula helenium roots, simultaneously inhibits Nur77 and activates AMPKα, significantly inhibiting adipogenesis in vitro and showing an anti-obesity effect in vivo [2].