In hepatoma cell lines Hep3B and PLC/PRF/5, TNF-induced EMT increased the expression of PD-L1, PD-L2, CD73, and B7-H3, while reversing EMT reduced the expression of PD-L1, PD-L2, CD73, and B7-H3. This evidence concerns the gene PDCD1LG2 and hepatocellular carcinoma.