CDKN1B and head and neck squamous cell carcinoma: The overexpression of miR-196a has been shown to significantly increase cell proliferation, migration, and invasion, and to induce EMT, possibly through targeting of ANXA1 [173] and MAMDC2 [174] in HNSCC cells, and of HOXB8 and p27 (CDKN1B) in OSCC cells [175].