Among the proteins with down-regulated N-glycosylation induced by 2DG, several were notable because of their profound implications in cancer, such as galectin 3-binding protein (LGALS3BP), carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), and epidermal growth factor receptor (EGFR). The gene discussed is LGALS3BP; the disease is cancer.