Consistent with this, suppression of ID1 increased promoter occupancy of TCF4 and TWIST1 on E-box containing CDH1 and CDH2 promoter loci [2], and increased TCF4 and TWIST1 were observed on CDH1 and CDH2 promoters in FOXA1 knockdown A549 lung cancer cells (Figure 4C). The gene discussed is TWIST1; the disease is lung carcinoma.