Figure 6C shows that TCF4 knockdown restored the decreased CDH1 and increased CDH2 and SNAI2 expression upon TGFβ1 treatment (Figure 6C). Increased promoter occupancy of TCF4 on CDH1 and CDH2 promoters was observed in the presence of TGFβ1 (Figure 6D). In addition, TCF4 promoter occupancy upon TGFβ1 treatment was significantly decreased in FOXA1 or PGC1α stably overexpressing A549 lung cancer cells (Figure 6D). Here, PPARGC1A is linked to lung carcinoma.