Figure 1C shows that PGC1α mRNA levels were downregulated in FOXA1 knockdown A549 and H358 cells. Similarly, PGC1α transcript levels were significantly increased in adenoviral FOXA1-transduced cells (Figure 1D). Figure 1E shows that overexpression of PGC1α largely increased FOXA1 expression in A549 and H358 lung cancer cells. In addition, ectopically expressed PGC1α interacted with FOXA1 (Figure 1F). This evidence concerns the gene PPARGC1A and lung cancer.