On the other hand, in a large study conducted by Edmin M. et al. [19] in a population with a prominent reduced ejection fraction (more than 80% with reduced left ventricular ejection fraction (LVEF) <40%) in a multivariate model (including age, sex, BMI, ischemic etiology, LVEF, NYHA classification, glomerular filtration rate, medical therapy, NT-proBNP, and hs-TnT), the risk of all-cause death, cardiovascular death, and HF hospitalization were increased by 26%, 25%, and 30%, respectively, per each doubling of sST2 [19]. Here, NPPB is linked to hydrops fetalis.