The American heart failure cohort study (PRIDE study) [17] firstly analyzed the role of sST2 in defining acute HF in patients enrolled in emergency department with acute dyspnea, and NT-proBNP was significantly superior to sST2; however, this study suggested that sST2 was more important as a prognostic tool, regarding mortality, due to HF. The gene discussed is NPPB; the disease is heart failure.