The American Heart Association/American College of Cardiology guidelines on the management of HF recommend the measurement of sST2, in addition to other fibrosis biomarkers, in patients with acute HF for a more appropriate stratification [14]; moreover, sST2, unlike NT-proBNP, is not influenced by age, body mass index (BMI), renal function, or the etiology of HF [15]. This evidence concerns the gene NPPB and hydrops fetalis.