Conversely, in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA) cohort, sST2 was significantly associated with secondary endpoints (worsening HF and hospitalization due to worsening HF) in older patients with chronic HF, whereas sST2 did not show prognostic significance regarding primary endpoint (CV death, non-fatal myocardial infarction, or stroke) pro-BNP, and C-reactive protein [24]. This evidence concerns the gene NPPB and hydrops fetalis.