The Prospective Randomized Amlodipine Survival Evaluation 2 (PRAISE-2) study conducted on severe chronic heart failure (NYHA class III to IV) suggested that the variation in sST2 during hospitalization, more than baseline sST2 value, is a significant predictor of end-point, beyond well-known predictive significance of baseline BNP and baseline precursor peptide of atrial natriuretic peptide (ProANP) [2]. Here, NPPA is linked to congestive heart failure.