The lifestyle intervention that improved both NASH and atherosclerosis, led to an opposite gene expression for all hepatic key regulators (Figure 3b), except C1R (lifestyle slightly attenuated the expression) and APCS (serum amyloid P component, lifestyle had no effect), thereby strengthening our postulate that these hepatic key regulators of NASH development drive the aortic key regulators and development of atherosclerosis. This evidence concerns the gene APCS and metabolic dysfunction-associated steatohepatitis.