Via the use of a novel in silico gene regulatory network analysis approach (dynGENIE3), we identified specific liver regulators related to lipid metabolism (such as SC5D, LCAT and HMGCR), inflammation (IL1A) and fibrosis (PDGF and COL3A1), linked to a set of aorta target genes related to vascular inflammation and atherosclerosis signaling. Here, SC5D is linked to atherosclerosis.