Similarly, SELP (selectin-P) deficiency, one of the hepatic key regulators that in our study was found to be upregulated and linked to atherosclerosis signaling via TNFSF11, reduces atherosclerosis in combined P-selectin/ApoE knock-out mice vs. ApoE single knock-out mice [37]. This evidence concerns the gene TNFSF11 and atherosclerosis.