TLR7 and systemic lupus erythematosus: As such, gut translocation of Enterococcus gallinarum, one of the pathobiont in some situations, to the liver and other organs trigger anti-dsDNA (the major autoantibody in lupus) through TLR-7/8 activation in New Zealand White (NZW)/F1 lupus mice (and also possibly in patients), which is attenuated by antibiotics, has been demonstrated [28].