CALR and systemic lupus erythematosus: Additionally, the antibody against Ro protein (Ro60, a 60 kDa self-antigens) that is commonly found in lupus, cross-reacts with the Ebstein–Barr virus nuclear antigen-1 (EBNA-1), and the ortholog Ro60-containing is demonstrated in Bacteroides thetaiotaomicron (gut commensal bacteria) in microbiome analysis from patients with SLE [138,139].