DE transcripts were statistically significantly associated with molecular pathways consistent with DKD pathogenesis such as inflammatory pathways (i.e., IL-5 signaling pathway, IL-2 signaling pathway, IL-11 signaling pathway), mitochondrial function (i.e., electron transport chain OXPHOS system, oxidative phosphorylation), UPR stress (i.e., cytoplasmic ribosomal proteins, major pathways of rRNA processing and cytosol) and fibrosis (i.e., VEGFA-VEGFR signaling pathway, interferon type 1 signaling pathway) (Figure 2). Here, KDR is linked to diabetic kidney disease.