CXCL8 and acute respiratory distress syndrome: There are a number of biomarkers proposed to predict the morbidity and mortality of ALI, including those found on the epitheilum (von Willebrand factor) and endothelium (ICAM-1, surfactant protein D, and receptor for advanced glycation end-products), and those involving inflammation (IL-6 and IL-8) and coagulation (protein C and plasminogen activator inhibitor-1) [22].