In animal models of ALI, MSCs have been demonstrated to decrease production of proinflammatory cytokines (IL-1α, IL-1β, IL-6, IL-8, MCP-1, MIP-2, IFN-γ, and TNF-α) and increase anti-inflammatory cytokines (IL-10) [24]. This evidence concerns the gene CXCL8 and acute respiratory distress syndrome.