We first looked in The Cancer Genome Atlas (TCGA) prostate adenocarcinoma (PRAD) Firehose cohort to compare EDEM1, EDEM2 and EDEM3 gene expression data in prostate adenocarcinoma tissue (n = 497) and normal prostate tissue (n = 52) [28]. The gene discussed is EDEM1; the disease is prostate adenocarcinoma.