Strikingly, Spearman correlation analysis from the TCGA PRAD cohort (n = 493) [28] showed that EDEM3 expression positively correlates with each of the UPR stress sensors; ERN1 (IFE-1α), EIF1AK3 (PERK) and ATF6 (Figure 2A–C). Here, ATF6 is linked to prostate adenocarcinoma.