Additionally, IFN-γ may contribute to hyperglycemia-induced reduction of platelet endothelial cell adhesion molecule-1 (PECAM-1), as a treatment of rat retinal microvascular endothelial cells (RRMECs) with IFN-γ (30 ng/mL) reduces PECAM-1 levels by 57%, possibly through increased ubiquitination and degradation. This evidence concerns the gene IFNG and Hyperglycemia.