High-fat diets have been found to induce hypertension accompanying by impairing several sodium transporters in the kidneys, like Na+/Cl− cotransporter (NCC), sodium hydrogen exchanger type 3 (NHE3), and Na-K-2Cl cotransporter (NKCC2) [30,53,54]. The gene discussed is SLC12A1; the disease is Hypertension.