Another study which focused on the immunological profile between patients with hep-B HCC vs. non-hep-B HCC revealed that tumor infiltrating lymphocytes of hep-B HCC clusters had a high abundance of T regs and elevated expression of PD-1 expression, whereas non-hep-B HCC clusters contained Tim-3+CD8+ T cells and NK cells [92]. The gene discussed is HAVCR2; the disease is hepatocellular carcinoma.