The expansion of Th17 cells expressing IL-17 and IFN-γ (DP-Th17) in draining lymph nodes (dLN) and spleen of p35-KI mice is of clinical relevance, as the DP-Th17 population is implicated in severe inflammatory diseases including uveitis [11,20], Crohn’s disease [26], candidiasis [27] and multiple sclerosis [28]. This evidence concerns the gene IL17A and multiple sclerosis.