KAT8 and colorectal cancer: In addition to H4K16 deacetylation, SIRT1 was reported to deacetylate a member of the HAT family called hMOF (human MOF), which consequently affected its recruitment at sites of DNA damage and caused downregulation of DNA double strand break repair genes such as BRCA2, RAD50, and FANCA in human colorectal cancer cells (HCT116) [42].