We observed an overexpression of TLR2 in the alveolar macrophages in COPD patients after costimulation with PA infection and the corticosteroids BUD and FLU, which was associated with higher NF-κB activity; however, this response was not observed in the COPD patients that were under ICS baseline treatment. The gene discussed is NFKB1; the disease is chronic obstructive pulmonary disease.