It is possible that the inhibition of IL-10 production in BAL from COPD patients caused by corticosteroids may hinder the resolution of inflammation within the lung (therefore supporting the upregulation of IL-8 in BAL), whereas, systemically, IL-10 levels would be upregulated instead, especially in patients under ICS treatment. This evidence concerns the gene CXCL8 and chronic obstructive pulmonary disease.