Viral infections can activate one of the four ISR stress kinases—the double-stranded RNA-dependent protein kinase (PKR) which is induced by interferon [75,76,77]—leading to the formation of SGs that not only enhance antiviral innate immune signaling [78] but also inhibit viral protein accumulation and replication [66,79]. The gene discussed is EIF2AK2; the disease is viral infectious disease.