MAVS and infection: However, in an in vivo VSV-infection mouse model, ALKBH5 can erase m6A-modified antiviral transcripts to prevent IFN translation and inhibit type I IFN production by binding to nuclear DDX46, inducing the retention of antiviral transcripts including MAVS in the nucleus, reducing the expression of MAVS, and inhibiting MAVS-induced activation of IFN-β luciferase reporter [836].