METTL3 and infection: Thus, the timely deactivation of GSK-3 by melatonin via inhibition of GSK-3 gene expression and the phosphorylation of GSK-3 can increase FTO levels and reduce METTL3 in the early stages of infection to effectively suppress not only viral phase separation by N protein, but also the global modulation of the epitranscriptome by the SARS-CoV-2 virus (Figure 2).