EIF2AK2 and myocarditis: The mammalian orthoreovirus uses its double-stranded RNA-binding protein σ3 to inhibit PKR activation and suppress SG formation, causing myocarditis in infected mice [82], while SARS-CoV-2 N protein inhibits PKR autophosphorylation and activation via an RNA-dependent interaction with PKR to suppress SG formation [80].