ALKBH5 and infection: Therefore, by disassembling SGs via manipulation of the GSK-3/Gle1 pathway, the SARS-CoV-2 virus can liberate and sequester DDX3X to facilitate binding with ALKBH5 to enhance immune evasion [802,843], whereas the timely inhibition of the GSK-3/Gle1 pathway during early infection stages by melatonin can protect the assembly of SGs and restrain DDX3Xs from binding excessively with ALKBH5 (Figure 2).