The SARS-CoV and SARS-CoV-2 viruses facilitate infection and replication, inhibiting immune responses by targeting the host transcriptome, suppressing host gene expression by degrading host mRNA, preventing IFN-β mRNA accumulation [56], and disrupting host mRNA splicing and protein translation to suppress IFN signaling pathways [55]. The gene discussed is IFNA1; the disease is infection.