An analysis of transcriptional profiles of bronchoalveolar lavage fluid (BALF) from severe COVID-19 patients exhibiting pneumonia revealed profound changes in mRNA levels of encoding proteins that regulate coagulation, fibrinolysis, and inflammation, where a reduction of 22-fold and 33-fold in transcripts encoding thrombomodulin and endothelial protein C receptor (EPCR), respectively, compared to controls, were detected [626]. The gene discussed is PROCR; the disease is pneumonia.